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高晓怡博士，河南平顶山人，特聘副研究员，理学博士。北京师范大学物理化学专业博士，清华大学博士后，长期从事光电生物传感器的开发与应用和生物分析化学的研究。 高晓怡博士已在Analytical Chemistry、ACS Sensors等学术刊物发表第一作者论文4篇，参与发表论文8篇，并申请中国专利2项。 |
主要科研成果
论文
[1] Gao, X., Teng, X., Dai, Y., Li, J.*,2021Rolling Circle Amplification Assisted Flow Cytometry Approach for Simultaneous Profiling of Exosomal Surface Proteins. ACS Sensors 6, 3611-3620.
[2] Gao, X., Qi, L., Liu, K., Meng, C., Li, Y.*, Yu, H.-Z.*,2020. Exonuclease I‑assisted general strategy to convert aptamer-based electrochemical biosensors from “signal-off” to “signal-on”. Analytical Chemistry 92, 6229-6234.
[3] Gao, X., Wang, X., Li, Y*., He, L., Yu, H.-Z.*,2018. Exonuclease I-hydrolysis assisted electrochemical quantitation of surface-immobilized DNA hairpins and improved HIV-1 gene detection. Analytical Chemistry 90, 8147-8153.
[4] Gao, X., Geng, M., Li, Y.*, Wang, X., Yu, H.-Z.*,2017. Revealing and resolving the restrained enzymatic cleavage of DNA self-assembled monolayers on gold: electrochemical quantitation and ESI-MS confirmation. Analytical Chemistry 89, 2464-2471.
[5] Wang, X.,Gao, X., He, L., Hu, X., Li, Y.*, Li, X., Fan, L., Yu, H.-Z.*,2019. Systematic truncating of aptamers to create high-performance graphene oxide (GO)-based aptasensors for the multiplex detection of mycotoxins. Analyst 144, 3826-3835.
[6] Shi, X.,Gao, X., Zhang, L., Li, Y.*, Fan, L., Yu, H.-Z.*,2015. Binary DNA hairpin-based colorimetric biochip for simultaneous detection of Pb2+and Hg2+in real-world samples. Analyst 140, 2608-2612.
[7] He, J., Hu, X.,Gao, X.,Meng, C., Li, Y.*, Li, X., Fan, L., Yu, H.-Z.*,2020. A versatile fluorometric in situ hybridization method for the quantitation of hairpin conformations in DNA self-assembled monolayers. Analyst 145, 4522-4531.
[8] Geng, M., He, J., Li, Y.*,Gao, X.,and Yu, H.-Z.*,2018. Quantitative comparison of three representative staining methods for the development of multichannel colorimetric biochips. Analytical Methods 10, 1715-1724.
科研项目
[1] Hairpin DNA在基片表面发卡状构型的高效形成、可控调控及其对弱结合刺激的响应研究（210100183），国家自然科学面上基金，2016.01-2019.12，78.4万，参与、结题；
[2] 适配体/氧化石墨烯复合信标平台的建立及其在食品有害污染物快检中的应用（2182026），北京市自然科学面上基金，2018.01-2020.12，20万，参与、结题。
其他科研业绩
[1] 李运超*，高晓怡，王杏林。“基于酶水解能力的基片表面HP DNA发卡构型的定量评测及背景信号消除方法”。专利公开号：CN108195919B.
[2] 李景虹*，高晓怡，滕续聪，戴依聪。“基于免疫磁珠和滚环扩增的外泌体膜蛋白的流式检测方法及应用”。专利申请号：202110360754.8.
