| 韩玉林博士,河南商丘人,青年教师,理学博士。 学习工作经历
2007.9-2012.6 中山大学理学学士 2012.9-2018.1 中国科学院上海有机化学研究所理学博士(导师:麻生明院士) 2018.1-2018.12 复旦大学助理研究员 2019.1-2021.7 美国纽约西奈山伊坎医学院博士后(合作导师:金坚教授) 2021.10- 浙江树人大学交叉科学研究院青年教师 博士期间从事过渡金属催化的手性联烯化合物的环化反应的研究;博士后期间主要从事表观遗传学修饰方向的研究,开发用于癌症治疗的组蛋白甲基化酶和DNA甲基化酶的选择性抑制剂和降解剂(PROTACs)。目前以第一作者在Angew. Chen. Int. Ed.,,Org. Chem. Front.,Chem. Eur. J.,Chin. J. Chem.等发表了SCI论文6篇,以通讯作者发表SCI论文1篇,其中一区2篇,二区4篇,三区1篇,参与发表SCI论文7篇。 研究领域:有机功能材料化学、金属有机化学和药物化学
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主要科研成果
论文
1. Yulin Han, Anni Qin, Qian Zhang, Xue Zhang,* Hui Qian,* Shengming Ma.* Rhodium-Catalyzed Dynamic Kinetic [4+2] Cycloaddition of Allene-1,3-Dienes. Angew. Chem. Int. Ed. 2022, 61, e202211635.(IF = 16.82,中科院一区,TOP)
2. Yulin Han, Shengming Ma.* Rhodium-catalyzed highly diastereoselective intramolecular [4+2] cycloaddition of 1,3-disubstituted allene-1,3-dienes. Org. Chem. Front. 2018, 5, 2680-2684.(IF = 5.46,中科院一区,TOP)
3. Yulin Han, Yichuan Zhao, Shengming Ma.* Rhodium-Catalyzed Pauson-Khand-Type Cyclization of 1,5-Allene-Alkynes: A Chirality Transfer Strategy for Optically Active Bicyclic Ketones. Chem. Eur. J. 2019, 25, 9529-9533.(IF = 5.02,中科院二区,TOP)
4. Yulin Han, Anni Qin, Shengming Ma.* One Stone for Three Birds-Rhodium-Catalyzed Highly Diastereoselective Intramolecular [4+2] Cycloaddition of Optically Active Allene-1,3-dienes. Chin. J. Chem. 2019, 37, 486-496.(IF = 5.56,中科院二区)
5. Yulin Han, Xue Zhang.* Theoretical Studies of Allene Synthesis through Cadmium Iodide-Mediated Allenylation of Terminal Alkynes. Asian J. Org. Chem. 2017, 6, 1778-1782.(IF = 3.12,中科院三区)
6. Yulin Han, Xinjun Tang, Jiajia Cheng, Shengming Ma.* Indium(III) Triflate-Catalyzed Efficient Prins-Type Cyclization of -Allenols and Aldehydes. Adv. Synth. Catal. 2016, 358, 4019-4029.(IF = 5.98,中科院二区)
7. Anni Qin, Qian Zhang, Hui Qian,* Yulin Han,* Shengming Ma.* Rh-Catalyzed Kinetic Resolution-Based Enantioselective [4+2]-Cycloaddition-Isomerization of Allene-1,3-dienes. Chin. J. Chem. 2021, 39, 559-565.(Breaking Report,IF = 5.56,中科院二区)
8. Xinjun Tang, Yulin Han, Shengming Ma.* Cadmium Iodide Mediated Allenylation of Terminal Alkynes for the Synthesis of Methyl-Substituted Allenes. Org. Lett. 2015, 17, 1176-1179.(IF = 6.07,中科院一区,TOP)
9. Martin Klima, Aliakbar Khalili Yazdi, Fengling Li, Irene Chau, Taraneh Hajian, Albina Bolotokova, H. Ümit Kaniskan, Yulin Han, Ke Wang, Deyao Li, Minkui Luo, Jian Jin, Evzen Boura,* Masoud Vedadi.* Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Protein Science. 2022, 31, e4395.(IF = 6.99,中科院三区)
专利
Jian Jin; Marta Filizola; Aneel Aggarwal; Samir Parekh; Abhijeet Kapoor; Shashidhar Jitian; H Kaniskan; Jianping Hu; Yudao Shen; Fanye Meng; Lihuai Qin; Yulin Han; Xufen Yu; Chengwei Zhang; Prashasti Kumar; Rinku Jain; Clement Lee; SOX11 inhibitors for treating mantle cell lymphoma, 2021-12-23 WIPO, WO2021257544A1.