| 宋中迪博士，山东聊城人，讲师，伦敦大学学院(UCL)生化工程专业工学博士，曾获UCL海外研究生奖学金(ORS)。长期从事光合微藻生物技术研究工作，围绕生物炼制和合成生物学两大概念，先后开展了微藻环境分子毒理、微藻生物能源、微藻生理生化、微藻放大培养及下游生物工艺等相关研究。现阶段以海洋硅藻为研究对象，主要从事1)微藻环境修复(phycoremediation)实现废水/气资源化：新型污染物微藻脱除机制，CO2/NOx的微藻生物减排；2)微藻生物炼制(biorefinery)和合成生物学(synthetic biology)实现藻资源利用：优化高价值天然产物如EPA、岩藻黄素产量及绿色生物能源转化。 宋中迪博士已在Molecular & Cellular Proteomics, Algal Research, Biotechnology for Biofuels, Frontiers in Microbiology等学术刊物发表SCI论文6篇。 |
主要科研成果
论文
[13] Wang L, Liu K, Song Z, Do H, Yang L, Wu J, Jiang L, Yu H. Influence of coordination number and ionic radius on metal ion preference and activity of lanthanide-dependent alcohol dehydrogenase: Insights from mutational studies and density functional theory. Colloids Surf B Biointerfaces. 2025, 251:114596.
[12] Pu Z, Cao J, Wu W, Song Z, Yang L, Wu J, Yu H. Reconstructing dynamics correlation network to simultaneously improve activity and stability of 2,3-butanediol dehydrogenase by design of distal interchain disulfide bonds. Int J Biol Macromol. 2024, 267(Pt 2):131415.
[11] Liu K, Jiang L, Ma S, Song Z*, Wang L, Zhang Q, Xu R, Yang L, Wu J, Yu H*. An evolved pyrrolysyl-tRNA synthetase with polysubstrate specificity expands the toolbox for engineering enzymes with incorporation of noncanonical amino acids. Bioresour Bioprocess. 2023, 10(1):92.
[10] Zhang Q, Zheng W, Song Z, Zhang Q, Yang L, Wu J, Lin J, Xu G, Yu H. Machine Learning Enables Prediction of Pyrrolysyl-tRNA Synthetase Substrate Specificity. ACS Synth Biol. 2023, 12(8):2403-2417.
[9] Song Z, Zhang Q, Wu W, Pu Z, Yu H. Rational design of enzyme activity and enantioselectivity. Front Bioeng Biotechnol. 2023, 11:1129149.
[8] Ji C, Song Z, Tian Z, Feng Z, Fan L, Shou C, Zhao M. Enantioselectivity in the toxicological effects of chiral pesticides: A review. Sci Total Environ. 2023, 857(Pt 3):159656.
[7] He J, Wang Z, Zhen F, Wang Z, Song Z, Chen J, Hrynsphan D, Tatsiana S. Mechanisms of flame retardant tris (2-ethylhexyl) phosphate biodegradation via novel bacterial strain Ochrobactrum tritici WX3-8. Chemosphere. 2023, 311(Pt 2):137071.
[6] Song Z, Lye GJ, Parker BM. Morphological and biochemical changes in Phaeodactylum tricornutum triggered by culture media: Implications for industrial exploitation. Algal Res. 2020, 47:101822.
[5] Sun T, Xu L, Wu L, Song Z, Chen L, Zhang W. Identification of a New Target slr0946 of the Response Regulator Sll0649 Involving Cadmium Tolerance in Synechocystis sp. PCC 6803. Front Microbiol. 2017, 8:1582.
[4] Song Z, Chen L, Wang J, Lu Y, Jiang W, Zhang W. A transcriptional regulator Sll0794 regulates tolerance to biofuel ethanol in photosynthetic Synechocystis sp. PCC 6803. Mol Cell Proteomics. 2014, 13(12):3519-32.
[3] Chen L, Zhu Y, Song Z, Wang J, Zhang W. An orphan response regulator Sll0649 involved in cadmium tolerance and metal homeostasis in photosynthetic Synechocystis sp. PCC 6803. J Proteomics. 2014, 103:87-102.
[2] Chen L, Wu L, Zhu Y, Song Z, Wang J, Zhang W. An orphan two-component response regulator Slr1588 involves salt tolerance by directly regulating synthesis of compatible solutes in photosynthetic Synechocystis sp. PCC 6803. Mol Biosyst. 2014, 10(7):1765-74.
[1] Zhu H, Ren X, Wang J, Song Z, Shi M, Qiao J, Tian X, Liu J, Chen L, Zhang W. Integrated OMICS guided engineering of biofuel butanol-tolerance in photosynthetic Synechocystis sp. PCC 6803. Biotechnol Biofuels. 2013, 6(1):106.
科研项目
[1] Y202147851，浙江省教育厅一般科研项目，2021.10-2024.10，主持；
[2] Y22B070545，浙江省自然科学基金一般项目，2022.01-2024.12，参与
