| 郭子立博士，山东枣庄人，特聘副研究员，工学学士、医学硕士、医学博士。她是浙江工业大学药物化学专业博士，环境科学与工程博士后，长期从事中药成分分析及药效物质基础等相关领域的研究工作。 在此前的研究工作中，她主持浙江省科技计划-重点研发项目（子课题）1项，浙江省教育厅科研项目1项，参与国家自然科学基金1项，国家其它科技项目1项，浙江省自然科学基金1项，浙江省科技计划项目2项。以项目技术负责人承担横向课题2项，参与横向项目研究10余项。参与翻译《早期药物开发 将候选药物推向临床》著作1本。 郭子立博士已在Food Chem, J Pharm Biomed Anal, J Mass Spectrom, J Sep Sci, Foods等学术刊物发表第一作者或共同第一作者论文13篇，参与发表论文6篇，并参与申请中国发明专利1项。 |
主要科研成果
论文
[1] Guo, Z.L., Liu, Y.L., Xiang, J.N., Liang, X.R., 2023. Mechanochemical preparation of red clover extract/β-cyclodextrin dispersion: Enhanced water solubility and activities in alleviating high-fat diet-induced lipid accumulation and gut microbiota dysbiosis in mice. Food Chemistry 420, 136084.
[2] Guo, Z.L., Chen, L.S., Liang, X.R., 2023. Components research on Tetrastigma hemsleyanum Diels et Gilg: Identification and effect of drying methods on the content of ten main constituents by targeting metabolomics method. Journal of Pharmaceutical and Biomedical Analysis 229, 115375.
[3] Guo, Z.L., Gu, J.P., Zhang, M., Su, F., Su, W.K., Xie, Y.Y., 2023. NMR-Based Metabolomics to Analyze the Effects of a Series of Monoamine Oxidases-B Inhibitors on U251 Cells. Biomolecules 13, 600.
[4] Guo, Z.L., Lai, J.X., Wu, Y.W., Fang, S., Liang, X.R., 2023. Investigation on Antioxidant Activity and Different Metabolites of Mulberry (Morus spp.) Leaves Depending on the Harvest Months by UPLC–Q-TOF-MS with Multivariate Tools. Molecules 28, 1947.
[5] Guo, Z.L., Gao, B.B., Fan, M.L., Chen, L.S., Zhang, C.J., Liang, X.R., Su, W.K., Xie, Y.Y., 2023. Study on Absorption, Distribution and Excretion of a New Candidate Compound XYY-CP1106 against Alzheimer’s Disease in Rats by LC-MS/MS. Molecules 28, 2377.
[6] Guo, Z.L., Zhu, P.X., He, X.A., Yan, T.H., Liang, X.R., 2021. Components identification and isomers differentiation in pigeon pea (Cajanus cajan L.) leaves by LC-MS. Journal of Separation Science 44(13), 2510–2523.
[7] Guo, Z.L., Cheng, J.Y., Zheng, L., Xu, W.H., Xie, Y.Y., 2021. Mechanochemical-assisted extraction and hepatoprotective activity research of flavonoids from sea buckthorn (Hippophaë rhamnoides L.) pomaces. Molecules 26(24), 7615.
[8] Guo, Z.L., Xiong, S.T., Xie, Y.Y., Liang, X.R., 2021. The separation and purification of ellagic acid from Phyllanthus urinaria L. by a combined mechanochemical-macroporous resin adsorption method. Separations 8(10), 186.
[9] Xia, J.J., Guo, Z.L., Fang, S., Gu, J.P., Liang, X.R., 2021. Effect of drying methods on volatile compounds of burdock (Arctium lappa L.) root tea as revealed by gas chromatography mass spectrometry-based metabolomics. Foods 10(4), 868.
[10] Han, N., Ye, Q., Guo, Z.L., Liang, X.R., 2023. Metabolomics analysis of differential chemical constituents and α-glucosidase inhibiting activity of Phyllanthus urinarial L. root, stem, leaf and fruit. Natural Product Research 37(4), 642–645.
[11] Jiang, X.L., Chen, S.H., Guo, Z.L., Gu, D., Liang, X.R., 2021. Components characterisation of Berchemia lineata (L.) DC. by UPLC-QTOF-MS/MS and its metabolism with human liver microsomes. Natural Product Research 35(3), 521–524.
[12] Liang, X.R., Jiang, Y., Guo, Z.L., Fang, S., 2020. Separation, UPLC-QTOF-MS/MS analysis, and antioxidant activity of hydrolyzable tannins from water caltrop (Trapa quadrispinosa) pericarps. LWT - Food Science and Technology 133, 110010.
[13] Guo, J.N., Mi, Z.S., Jiang, X.Y., Zhang, C.J., Guo, Z.L., Li, L.Z., Gu, J.P., Zhou, T., Bai, R.R. Xie, Y.Y., 2021. Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects. Bioorganic Chemistry 108, 104564.
[14] 郭子立, 夏骏杰, 韩宁, 顾金苹, 苏凤, 梁现蕊, 谢媛媛, 2020. 猫须草UPLC指纹图谱的建立及其抗氧化活性研究. 发酵科技通讯49(4), 187–191.
科研项目
[1] 工业菌种基因组结构重排技术体系的创建（2021YFC2100800），国家重点研发计划子课题，2021.07-2024.07，138万，参与、在研；
[2] 候选药物开发研究-基于 MAO-B 和生物铁代谢多靶点新型抗阿尔兹海默病候选药物的研发（2021C03085），浙江省重点研发项目子课题，2021.01-2023.12，100万，主持、在研；
[3] 三叶青多糖的提取、纯化及结构表征（Y202043200），浙江省教育厅科研项目，2021.01-2022.12，1.25万，主持、结题。
